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KMID : 0357919700040020123
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Korean Journal of Pathology
1970 Volume.4 No. 2 p.123 ~ p.131
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Autoradiographic Studies of Early Incorporation of L-Leucine-U-l4C into the Gastrointestinal Tract of Burned Mice
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Abstract
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Florey(1960) and more recently Skoryna(1967) emphasized the intimate relationship
between mucin production and peptic ulcer. Skoryna had an idea that "gastric let" or
"let mechanism" was the sum of mechanism which protected the gastric wall against
mechanical and chemical injuries, and he insisted on the involvement of mucin
production in this Mechanism.
Selye(1950) reported about gastric ulcer following injuries, but he did not mention
mucus secretion in the formation of gastric ulcer in the systemic stress. Kim(1965)
revealed that injury induced not only regressive changes in the gastric mucosa but also
marked decrease of mucus secretion, and Kim and Kim(1968) applied the
autoradiographic technique with radioactive 35S
(Na352SO4) to the mucus secretion following
systemic injury and demonstrated that injury induced marked regressive changes and
also marked decrease of mucin production both in gastric mucosa and rectum.
Therefore the authors performed the autoradiographic observaton of early incorporation
of L-leucine-U-14C into the gastrointestinal tract in both of normal and
burned mice in order to confirm that injury may act on protein metabolism of the
gastrointestinal tract.
The results were as follows:
In the burned mice, the incorporation rate of L-leucine-U-14C into the
epithelial cells of the mucosa both of the esophagus and the duodenum reached its
maximum earlier and that of the stomach, the small intestine and the colon later than
those of normal mice. Brunner's glandular cells of the duodeum were enhanced the
protein synthesis following injuries.
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KEYWORD
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